Cannabis Use Linked to Abnormal Embryos in IVF

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September 11 2025

Key Findings

• THC, cannabis's active ingredient, is linked to higher rates of chromosomal abnormalities in early embryos.

• THC exposure disrupts chromosome sorting in immature egg cells.

• Studies show lower rates of embryos with correct chromosome numbers in THC-positive IVF patients.

Research Details

Two studies by a Toronto research team:

1. Lab Study: Exposed immature egg cells to THC, showing increased chromosomal errors.

2. Retrospective Study: Analyzed IVF patients' follicular fluid. THC-positive patients had 60% normal embryos vs. 67% in THC-negative group.

Expert Insights

• Cyntia Duval, lead author from University of Toronto: "THC induces chromosomal segregation errors in oocytes and embryos."

• Jamie Lo, Oregon Health & Science University: Findings align with known impacts of cannabis on male fertility and pregnancy.

Implications

• Cannabis use may worsen fertility and increase reproductive complications.

• Lab study showed 9% higher aneuploidy rates and doubled spindle abnormalities with THC exposure.

• Results specific to IVF patients under high hormonal stimulation, not necessarily generalizable.

Context

• Cannabis is legal in Canada and much of the U.S., with rising use.

• Public health experts warn of unintended reproductive health consequences.

• Many cannabis users conceive successfully, so findings are a data point, not a definitive warning.

Source