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Using Tobacco With Cannabis Is Tied to Unique Brain Changes, Small Study Finds

OG article by Carly Cassella


November 7, 2025





In a small study, co-users of tobacco and cannabis showed elevated brain enzyme FAAH levels versus cannabis-only users, altering endocannabinoid regulation of bliss-linked neurotransmitters. This may underpin higher addiction and mental health risks in co-users. Published in Drug and Alcohol Dependence Reports, the findings highlight unique neurochemical impacts, warranting larger studies on polysubstance effects.

 
 
 

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