New Review Highlights CBD’s Potential in Skin, Wound Healing, and Oral Health

OG Article By Erin McEvoy

October 02 2025

Overview

A 2025 review in Biomolecules highlights CBD’s potential for skin conditions, wound healing, and oral health. Published in August 2025, it explores CBD’s benefits and delivery challenges.

Key Findings

• Properties: CBD offers anti-inflammatory, antioxidant, and antimicrobial effects via the skin’s endocannabinoid system (ECS).

• Skin Conditions: Effective for acne, dermatitis, alopecia, psoriasis, pruritus, calciphylaxis, epidermolysis bullosa, pyoderma gangrenosum, and skin cancer.

• Mechanisms: Reduces cell proliferation, stimulates apoptosis, and suppresses tumor angiogenesis in skin cancer.

• Wound Healing: Controls immune responses, cytokine activity, and oxidative stress for acute and chronic wounds.

• Anti-Aging: Modulates biomarkers for potential rejuvenation effects.

• Oral Health: Supports dental pulp repair, pain management, and infection control.

Delivery Challenges

• Absorption: CBD struggles to penetrate deep skin layers due to low water solubility.

• Solutions: New delivery systems needed for consistent therapeutic results.

Applications

• Dermatology: Topical CBD targets skin disorders with minimal systemic side effects.

• Cosmetics: Potential for anti-aging products, pending further safety testing.

• Dentistry: Promising for pain and infection management, but dosing and mechanisms need more research.

Limitations

• Research Gaps: Long-term effects and optimal formulations unclear.

• Regulations: Evolving laws require rigorous safety testing.

• Tolerability: Short-term use appears safe, but more data needed.

Future Outlook

CBD’s therapeutic potential in dermatology, cosmetics, and oral health is promising. Continued innovation and research could make it a key ingredient.

Source: Cannabis Science and Technology