New Cannabinoid Discovered: Cannabizetol

OG Article by Anthony Martinelli in News, Studies

September 26 2025

Overview

• Università degli Studi di Milano team discovers cannabizetol (CBGD).

• Shows strong antioxidant and anti-inflammatory effects on skin.

• Third known methylene-bridged dimeric cannabinoid.

Key Findings

• Identification: Isolated from Cannabis sativa extracts.

• Confirmation: Matches chemically synthesized standard.

• Effects: Outperforms cannabitwinol in skin cell tests.

  • Inhibits inflammatory markers (NF-κB, IL-8).

  • Suppresses pro-inflammatory genes linked to skin conditions.

• Potential: Promising for dermatological treatments.

Methodology

• Source: Extracted from cannabis, verified synthetically.

• Testing: Conducted on human keratinocytes.

• Synthesis: Used continuous flow chemistry.

  • Cuts reaction times compared to batch methods.

  • Modest yields, but reliable for research.

Significance

• Cannabizetol is rare, under 0.1% of cannabis content.

• Highlights uncharted “cannabinome” (150+ cannabinoids known).

• Opens doors for new skin health and therapeutic applications.

Future Directions

• Further studies needed to explore clinical potential.

• Optimized synthesis supports ongoing research.