New Cannabinoid Discovered: Cannabizetol
- barneyelias0
- Sep 26
- 1 min read
Updated: 5 days ago
OG Article by Anthony Martinelli in News, Studies
September 26 2025
Overview
Università degli Studi di Milano team discovers cannabizetol (CBGD).
Shows strong antioxidant and anti-inflammatory effects on skin.
Third known methylene-bridged dimeric cannabinoid.
Key Findings
Identification: Isolated from Cannabis sativa extracts.
Confirmation: Matches chemically synthesized standard.
Effects: Outperforms cannabitwinol in skin cell tests.
Inhibits inflammatory markers (NF-κB, IL-8).
Suppresses pro-inflammatory genes linked to skin conditions.
Potential: Promising for dermatological treatments.
Methodology
Source: Extracted from cannabis, verified synthetically.
Testing: Conducted on human keratinocytes.
Synthesis: Used continuous flow chemistry.
Cuts reaction times compared to batch methods.
Modest yields, but reliable for research.
Significance
Cannabizetol is rare, under 0.1% of cannabis content.
Highlights uncharted “cannabinome” (150+ cannabinoids known).
Opens doors for new skin health and therapeutic applications.
Future Directions
Further studies needed to explore clinical potential.
Optimized synthesis supports ongoing research.
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