Study Finds Cannabis Use Associated With Lower Odds of Common Sinonasal Diseases

OG Article By Anthony Martinelli in News, Studies

October 10 2025

Study Overview

A study in Laryngoscope Investigative Otolaryngology.Conducted by researchers from:

• Louisiana State University

• Texas A&M School of Medicine

• University of Houston

• Houston Methodist Hospital

Used NIH AllOfUs database.Compared 25,000+ cannabis users to 113,000+ non-users.

Key Findings

Cannabis use linked to lower risk of:

• Chronic rhinosinusitis (CRS)

• Allergic rhinitis (AR)

• Chronic rhinitis (CR)

Risk Reductions:

• Daily users:

  • CRS: 36% lower (OR 0.64, 95% CI 0.53-0.78)

  • AR: OR 0.64

• Weekly users:

  • CRS: 39% lower (OR 0.61, 95% CI 0.48-0.77)

  • AR: OR 0.62

• Monthly users:

  • CRS: 20% lower (OR 0.80)

  • AR: OR 0.69

  • CR: Lowest risk (OR 0.41)

Consumption Method

Smoking vs. non-smoking cannabis:No significant difference in CRS incidence (HR 0.64, 95% CI 0.27-1.5).

Conclusions

Largest study on cannabis and sinonasal diseases.Cannabis users show lower odds of AR, CRS, and CR.Findings supported by large cohort and demographic data.Route of use doesn’t affect CRS rates.Caution urged due to recreational cannabis risks.Calls for research into cannabinoid anti-inflammatory effects.

Implications

Rising cannabis use in the U.S.Need for molecular research on benefits and risks.Potential for cannabinoid-based treatments for chronic conditions.