OG article by Anthony Martinelli December 26, 2025 An observational study followed 137 new medical marijuana patients in Pennsylvania over one year, assessing sleep quality via the Pittsburgh Sleep Quality Index. Participants completed surveys at baseline and 3, 6, 9, and 12 months. Global sleep scores improved significantly from baseline to the first follow-up, with gains sustained throughout the year without further progression. Subscales reflected consistent benefits in l

OG article by Anthony Martinelli December 26, 2025 A study in the Journal of Ethnopharmacology examined cannabidiol (CBD)'s hepatoprotective effects in a mouse model of acute liver injury induced by lipopolysaccharide and D-galactosamine. Chinese researchers administered CBD at 2.5 and 5 mg/kg doses. Treatment markedly lowered serum markers of liver damage, including alanine and aspartate aminotransferase. Histopathology showed reduced tissue injury, while assays revealed de

OG article by Anthony Martinelli December 26, 2025 President Trump issued an executive order directing Attorney General Pam Bondi to expedite the rescheduling of marijuana from Schedule I to Schedule III under the Controlled Substances Act, targeting completion by January 2026 end. The order mandates coordination with Health and Human Services, building on their 2023 recommendation. It emphasizes adhering to federal law while avoiding delays in rulemaking. Rescheduling would

OG article by Anthony Martinelli December 26, 2025 A recent study in Archives of Biochemistry and Biophysics explored CBD-loaded biohybrid micelles for enhanced anti-cancer activity in colon cancer. Researchers from East China University of Science and Technology developed micelles using polyethylene glycol, chitosan, bile acid, and quercetin to overcome CBD's poor solubility, low bioavailability, and non-targeted distribution. In vitro tests on HCT116, HT29, and Caco-2 colo

OG article by University of California - Los Angeles Health Sciences December 26, 2025 A comprehensive review published in JAMA Psychiatry analyzed over 2,500 studies on medical cannabis from 2010 to 2025, prioritizing 120 high-quality randomized clinical trials, meta-analyses, and guidelines. Researchers found substantial evidence gaps for most claimed benefits, despite widespread public use for conditions like chronic pain, anxiety, and insomnia. A 2018 survey indicated 27

OG article by Shaun Salvaje December 26, 2025 According to a filing submitted to the Texas Secretary of State, the Executive Commissioner of the Texas Health and Human Services Commission—on behalf of the Department of State Health Services—has proposed amendments to Title 25, Chapter 300, the rules governing the manufacture, distribution, and retail sale of consumable hemp products in Texas. These rules trace back to House Bill 1325, which created Texas Health and Safety Cod

OG article by Beth LeBlanc and Craig Mauger December 23, 2025 The Michigan Cannabis Industry Association has filed an appeal challenging a Court of Claims ruling that upheld a newly enacted 24% wholesale tax on recreational marijuana transactions, effective January 1, 2026. The group contends the tax unlawfully amends the 2018 voter-approved Proposal 1, which legalized adult-use cannabis and imposed only a 10% retail excise tax while referencing potential "other taxes" but r

OG article by Jacob Sullum December 23, 2025 President Donald Trump's executive order directing the swift rescheduling of marijuana from Schedule I to Schedule III under the Controlled Substances Act validates decades of criticism regarding its overly restrictive classification since 1970. Schedule I designation reserved for substances with high abuse potential and no accepted medical use placed marijuana alongside heroin and LSD, despite evidence to the contrary. As early a

OG article by Dalton Zbierski December 23, 2025 In Connecticut, state laws create distinct holiday restrictions across regulated industries. On Christmas Day (December 25) and New Year's Day (January 1), package stores, grocery stores selling alcohol, and manufacturers are prohibited from selling alcoholic beverages for off-premise consumption. Restaurants and bars may serve alcohol only for on-site enjoyment alongside food, with no take-out options permitted. The Department

OG article by Kelly Milan December 23, 2025 President Donald Trump's recent executive order reclassifying marijuana from Schedule I to Schedule III has sparked renewed discussions at the Tennessee State Capitol, though it does not legalize cannabis or change state laws. The shift acknowledges marijuana's potential medical benefits, previously hindered by restrictive classification alongside drugs like heroin. This reclassification eases research barriers and recognizes thera

OG article by Tom Angell December 23, 2025 Senator John Hickenlooper (D-CO) has introduced the Preparing Regulators Effectively for a Post-Prohibition Adult-Use Regulated Environment Act (PREPARE Act). This bipartisan-supported legislation requires the U.S. Attorney General to establish a Commission on the Federal Regulation of Cannabis within 30 days of enactment. The commission's primary task is to develop a comprehensive federal regulatory framework for cannabis by studyi

OG article by Travis Cullen. December 25 2025 My name is Travis Cullen. When I was 21 in 2004, I got caught trafficking 700 pounds of California marijuana. I was a first-time felon and I spent 8 years in federal prison for cannabis. I got arrested during the Bush JR administration. Back in 2004, the directive was simple: charge the max. That was pushed by Attorney General John Ashcroft and then carried on by Alberto Gonzales. And trust me — those directives mattered. They mat