New research finds that cannabinol (CBN), a lesser-known compound found in marijuana, could play a protective role in treating neurodegenerative diseases by reducing cell stress and promoting neuronal

OG Article  Written By Anthony Martinelli in News, Studies Watch Today's LIVE Episode on YouTube, X, and Rumble

June 27, 2025

This investigation, carried out by scientists from the University of Eastern Piedmont and the University “G. d’Annunzio” Chieti-Pescara and featured in the journal Antioxidants, delved into the impacts of CBN on differentiated neuroblastoma x spinal cord (NSC-34) cells. Experts subjected these cells to varying amounts of CBN over 24 hours and examined alterations in gene expression utilizing next-generation sequencing.

The study’s summary indicates, “Our findings demonstrate that CBN had no adverse influence on cell viability at the concentrations evaluated. Instead, it exhibited a notable effect on stress response and processes linked to neuroplasticity.” The information revealed that CBN influenced genes connected to cellular strain, nerve cell survival, and axon direction—crucial functions that frequently decline in neurodegenerative conditions.

In their concluding remarks, the researchers assert that CBN “boosts the antioxidant defense via the Nrf2 pathway and lessens susceptibility to programmed cell demise,” implying it might aid cells in enduring persistent strain. They further state that CBN “could potentially bolster neuronal well-being under circumstances of enduring stress,” though they underscore the necessity for in vivo studies to validate its safety and effectiveness.

These discoveries expand upon prior research emphasizing CBN’s antioxidant and anti-inflammatory characteristics and propose it could function as a supplementary treatment in the battle against neurodegenerative ailments such as Alzheimer’s and Parkinson’s.