Study: CBD Triggers Cancer Cell Death and Suppresses Melanoma Spread Through Epigenetic Pathway

OG article by Anthony Martinelli

January 9, 2026

CBD shows promise against melanoma via epigenetic mechanisms. A Phytomedicine study from Chinese researchers found CBD induced apoptosis, inhibited proliferation, and reduced metastasis in cell lines and mouse models. It activates PPARγ, forming a complex that demethylates LRSAM1, enhancing anti-tumor effects. This first evidence of CBD modulating gene methylation positions it as a safer alternative to chemotherapy for aggressive skin cancer.